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Twine Ventures

San Francisco, California · Invests in US · Website

Pre-SeedSeedSeries AAI & Machine LearningDeveloper ToolsData & AnalyticsFintechHealthcare & BiotechClimate & EnergyHealthcare & Digital HealthClimate & Clean EnergyFintech & PaymentsDeveloper Tools & Infrastructure

Thesis

Healthcare systems and climate-impacted industries are in generational transformation. We partner with mission-driven founders building enabling technologies—data, AI, software infrastructure—to accelerate this transition. Purpose and profit are inextricably linked.

Likely not a fit for

Non-mission-driven companies, hardware-only plays, companies not aligned with health or climate impact

How they invest

Lead or follow
Usually leads
Typical decision
~2 weeks
Warm intro
Not required
Involvement
Advisor
Fund status
Actively deploying
Assets under mgmt
$25M
Decision process
Partnership vote

Partners & team

2 contacts on file

LS

Leshika Samarasinghe

General PartnerFounder & Managing Partner · Primary contact

+ Pitch

LinkedIn profile

X profile

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EY

Ethan Yeh

General PartnerManaging Partner

+ Pitch

Portfolio

Apella TechnologyHealthcare Digital

Apella Technology Inc. provides a platform that may involve the collection and management of protected health information, focusing on compliance with HIPAA regulations.

Alchemy HealthHealthcare Digital

Alchemy Health builds and operates in-house pharmacies for safety net clinics, providing the physical, clinical, and digital infrastructure needed to operate and grow a best-in-class entity-owned in-house 340B pharmacy program.

WaymarkHealthcare Digital

Waymark connects individuals receiving Medicaid with local care teams, including community health workers, therapists, and pharmacists, to provide comprehensive support for physical and mental health.

Waltz HealthHealthcare Digital

Waltz Health is creating a smarter pharmaceutical marketplace that empowers consumers to find the best prescription prices and improve care while creating savings.

RupahealthHealthcare Digital

Rupa Health is a platform for ordering lab tests, partnering with over 30 labs to simplify the testing process. It offers a single dashboard for managing lab orders and provides support through a Patient Portal, focusing on root-cause medicine.

Alpha GridEnterprise Software

Alpha Grid is the AI platform that turns volatile EV charging revenue into predictable, optimized, bankable cash flows, providing real-time competitive intelligence for EV charging networks.

VerseEnterprise Software

Verse delivers energy cost intelligence for the enterprise. Through our AI-powered platform, Aria, we help energy, finance, and operations teams plan, procure, and control energy cost, risk, and emissions—all in one unified platform.

Plover ParametricsInsurance

Plover is a venture-backed specialty brokerage focused on parametric insurance solutions for natural catastrophes, weather-related risks, and other novel risks, leveraging technology to enhance service delivery.

Zipline AIEnterprise Software

Zipline AI is a modern infrastructure-as-code platform that simplifies building and deploying machine learning pipelines.

RowspaceEnterprise Software

Rowspace is focused on leveraging AI technologies to enhance data processing and analytics.

AldenHealthcare Digital

Alden is an AI-powered communications agent built to simplify your practice's administrative workflows. It integrates seamlessly with existing systems to handle inbound and outbound communications, prioritize messages, and ensure vital information reaches the right team members around the clock.

Colla HealthHealthcare Digital

Colla Health provides cancer-specific mental health services, focusing on the emotional, behavioral, and psychosocial needs of cancer patients. Their offerings include individual therapy, medication management, and remote crisis intervention, all designed to integrate seamlessly with oncology practices.

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Research briefRead more
Twine Ventures Research Investment Thesis Twine Ventures partners with early-stage founders for whom purpose and profit are inextricably linked. The firm believes that healthcare systems and climate-impacted industries are in the midst of generational transformation, and they invest in audacious teams building the enabling technologies—data, AI, and software infrastructure—that will accelerate thi

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