Polychain
San Francisco, California · Invests in US; Asia; UK · Website
Check size
$1M-$50M
Thesis
Blockchain-based digital assets represent a new asset class with mathematical scarcity. We invest in protocols and infrastructure building the foundational layer of decentralized internet, combining venture capital with active hedge fund portfolio management to capture long-term protocol upside and near-term market opportunities.
Likely not a fit for
We avoid non-technical teams, projects focused on quick exits rather than long-term protocol development, and ventures without clear economic/cryptographic innovation.
How they invest
- Lead or follow
- Usually leads
- Typical decision
- ~1 month
- Warm intro
- Preferred
- Involvement
- Takes a board seat
- Fund status
- Actively deploying
- Assets under mgmt
- $5B
- Decision process
- Partnership vote
Partners & team
3 contacts on file
Olaf Carlson-Wee
Founder, Chief Executive Officer · Primary contact
Josh Rosenthal
Partner and Portfolio Manager
Cortney Smith
Head of Asset Operations
Portfolio
ETHGas.io provides real-time gas price estimates for Ethereum transactions.
Cascade is a biotechnology company that specializes in developing cell-free biocatalysts, branded as Body Armor for Enzymes™, which significantly enhance enzyme performance and stability. Their innovative approach allows for the use of stabilized enzymes on silica beads, making them versatile and easy to integrate into existing processes across various industries.
Andrena provides high-speed Internet services starting at $30 per month, focusing on affordability and simplicity for residents and businesses. Their service includes plans up to 1 Gbps with no hidden fees and quick setup.
Polygon is a leading blockchain platform designed for payments, offering a suite of solutions that enhance cross-chain interoperability and streamline transactions. With a focus on lower-cost, efficient payment rails, Polygon integrates stablecoins and supports a variety of on-chain assets, making it a go-to choice for developers and users alike.
Eclipse Automation is a trusted leader in delivering cutting-edge manufacturing automation solutions, tailored to the unique needs of each client. They harness multi-industry know-how and the power of vertical integration to provide seamless custom automated systems that bring customers’ products to life.
Compound is a decentralized finance platform that offers an algorithmic interest rate protocol for developers. It aims to create open financial applications.
Aave is a decentralized non-custodial liquidity protocol that allows users to supply and borrow assets, earning interest on their deposits and accessing liquidity against collateral.
Uniswap is a decentralized protocol that enables peer-to-peer trading of digital assets using Automated Market Makers (AMMs), allowing users to swap tokens, lend, borrow, and build in a decentralized finance (DeFi) ecosystem.
Coinbase is a leading cryptocurrency exchange platform that allows users to buy, sell, and trade a variety of cryptocurrencies including Bitcoin and Ethereum. It also offers services for businesses and institutions, providing tools for crypto trading, payments, and asset management.
Sequence is a financial technology company and a consulting firm specializing in biopharmaceutical manufacturing, offering consulting services and solutions for the pharmaceutical, biotech, and life-science industries.
Valora is a mobile crypto wallet that allows users to save, earn, and send cryptocurrencies easily, focusing on accessibility and user-friendliness.
Recent activity
- Mar 2026
Silhouette
Seed · Lead
- Mar 2026
VeryAI
Seed · Lead
- Dec 2025
ETHGas
Seed · Lead
- Dec 2025
Cascade
Seed · Lead
- Dec 2025
DAWN
Series B · Lead
- Dec 2025
Andrena
Series B · Lead
- Nov 2025
Berachain
Growth · Lead
- Oct 2025
Glue
Series A · Lead
Polychain in the news
FX News Group
ASIC disqualifies former Polychain director Ashod Balanian for five years
3 months ago
The Block
Polychain Capital leads $110 million investment to kickstart a Berachain crypto treasury
9 months ago
GlobeNewswire
Digital Ascension Group and Polychain Capital Host Exclusive Kickoff Event for SF Fund Week 2025
9 months ago
Fortune
Exclusive: Crypto startup M0 raises $40 million to build out stablecoin network
10 months ago
CoinDesk
Stablecoin News: Startup M0 Raises $40M Series B From Polychian, Ribbit, Others
10 months ago
NFTgators
Stablecoin Startup M0 Secures $40M Funding Co-Led by Polychain and Ribbit Capital
11 months ago
dlnews.com
PIP Labs raises $80m from a16z and Polychain to develop Story, a blockchain for intellectual property
Aug 2024
Bloomberg.com
Polychain Makes Payouts to Investors in Two of Crypto VC Firm’s Funds
May 2024
Fortune
Former Polychain partners raise $25 million for Ritual, a startup focused on decentralizing AI
Nov 2023
CoinDesk
Crypto VC Firm Polychain Capital Raises $200M for Fourth Fund: Fortune
Jul 2023
The Block
Polychain Capital eyes $400 million raise for fourth fund
Mar 2023
WSJ
Crypto Fund Polychain’s Assets Drop 40% From $1 Billion Mark
Apr 2019
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