Boulder Ventures
Boulder, Colorado · Invests in US · Website
Check size
$1M-$5M
Thesis
We invest in early-stage information technology and biotechnology companies in Colorado and the Mid-Atlantic. Our philosophy is rooted in mountain guide principles: careful pattern recognition under uncertainty, patience in waiting for proper conditions, and a commitment to realized returns over paper valuations. We provide hands-on operational partnership, board-level involvement, and access to deep regional networks built over decades.
Likely not a fit for
We do not invest in consumer-facing applications without defensible moats, pure hardware plays, non-technical founding teams in IT sectors, or business models dependent on hypergrowth without sustainable unit economics.
How they invest
- Lead or follow
- Usually leads
- Typical decision
- ~1 month
- Warm intro
- Preferred
- Involvement
- Takes a board seat
- Fund status
- Actively deploying
- Assets under mgmt
- $500M
- Decision process
- Partnership vote
Partners & team
5 contacts on file
Kyle Lefkoff
Founder & General Partner · Primary contact
Peter Roshko
General Partner
Kishen Mangat
General Partner
Jonathan Perl
General Partner
Matthew Paul
Chief Financial Officer
Portfolio
Array BioPharma focuses on developing targeted therapies for cancer and other diseases, emphasizing innovative drug discovery and development processes.
NeXstar Pharmaceuticals is a company specializing in pharmaceutical products.
Dharmacon offers a range of reagents for functional genomics, specializing in RNAi and CRISPR technologies.
Genomica is a pioneer in molecular diagnostics and genetic identification, specializing in in-vitro diagnostics and automated solutions that adhere to high scientific and regulatory standards.
Miragen Therapeutics focuses on developing treatments for autoimmune diseases, known for its work in antibody discovery.
ArcherDX provides software and databases for genomic analysis, particularly focusing on gene fusion data relevant to cancer research.
Mineralys specializes in selling collectible minerals, fossils, and artisanal jewelry made from natural stones. The company operates an online store with a wide selection of semi-precious stones and handcrafted jewelry.
Stardog is a Semantic AI Platform that enables organizations to connect, integrate, and analyze data across various sources, leveraging knowledge graphs and AI technologies.
Antithesis tests complex distributed systems. It automates end-to-end system testing and finds the unknown unknowns that traditional testing methods miss.
Synaptic helps healthcare, government, and technology organizations leverage AI to compete in today's marketplace. We provide vertical AI solutions that extend Salesforce environments with purpose-built apps and AI agents.
Travel Curious offers authentic private tours led by handpicked guides, providing bespoke local experiences and avoiding crowds.
Recent activity
- Mar 2026
Ambrosia Biosciences
Series B · Participated
- Feb 2026
Comeryx
Seed · Participated
- Feb 2026
RapidFort
Series A · Participated
- Jan 2026
Synaptic Era
Seed · Lead
- Dec 2025
Antithesis
Series A · Investor
- Nov 2025
RapidFort
Series A · Participated
- Sep 2025
Stardog
Growth · Investor
- Aug 2025
Travel Curious
Growth · Investor
Boulder Ventures in the news
Fierce Biotech
Obesity biotech Ambrosia scores $100M series B to take next-gen oral GLP-1 into the clinic
3 months ago
Axios
EnerVenue's $300m, KNDS mega IPO, and Carlyle's RIA deal
3 months ago
AlleyWatch
The Weekly Notable Startup Funding Report: 2/9/26
5 months ago
Venture Capital Journal
Boulder Ventures targets $60m for ninth flagship fund
6 months ago
Failory
Top 11 Venture Capital Firms in Boulder (2026)
7 months ago
University of Colorado Boulder
Trailblazing ideas and entrepreneurial spirit reap rewards at the 2025 NVC Finals | New Venture Challenge
Apr 2025
The Business Journals
VC firm with Boulder office raises $102M fund, grows local team
Sep 2024
The Business Journals
Boulder VC firm closes $58M fund for Colorado and mid-Atlantic startups
Dec 2022
citybiz
Boulder Ventures Closes 8th Fund at $58 Million
Dec 2022
Founder Institute
Denver and Front Range Startup Resource List: 700+ Accelerators, Incubators, Investors, and more
Oct 2020
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Research briefRead more
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