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Asymmetry Ventures

San Francisco, CA · Invests in US · Website

SeedPre-SeedAI & Machine LearningDeveloper ToolsHealthcare & BiotechClimate & EnergySpace & DefenseHardware & DevicesBiotech & Life SciencesClimate & Clean EnergyAerospace & DefenseSemiconductors & HardwareHealthcare & Digital HealthDeveloper Tools & Infrastructure

Thesis

Backing transformative startups with exceptional defensibility and civilization-level impact potential. Focus on technical complexity, defensible innovation, and companies solving large-scale problems. Quality over volume approach with selective, thesis-driven investing.

Likely not a fit for

Pure consumer social apps. Traditional enterprise SaaS without defensible innovation. Service-based or labor-intensive models. Low-tech or commodity businesses. Companies without clear technical defensibility.

How they invest

Lead or follow
Usually follows
Typical decision
~2 months
Warm intro
Preferred
Involvement
Takes a board seat
Fund status
Actively deploying
Decision process
Partnership vote

Partners & team

5 contacts on file

RN

Rob Ness

General PartnerGeneral Partner · Primary contact

+ Pitch
DG

Daniel Gould

Venture PartnerVenture Partner

+ Pitch
KC

Kelly Carroll

Team Member

+ Pitch
AS

Alex Shlyankevich

Team Member

+ Pitch
MP

Matteo Palamà

Team Member

+ Pitch

Portfolio

Atomic AlchemyBiotech Life Sciences

Atomic Alchemy is building scalable U.S. radioisotope production capabilities in U.S.-based facilities dedicated to producing essential isotopes for healthcare, industry, research, and defense.

BTQ TechnologiesSecurity Cyber

BTQ delivers quantum advantage through cost-efficient solutions that create new markets and disrupt existing industries, focusing on post-quantum cryptography and quantum solutions.

CyberdonticsHealthcare Digital

Cyberdontics is revolutionizing modern dentistry through advanced imaging, AI, and robotics, helping dentists diagnose and treat patients more effectively.

CytoReasonBiotech Life Sciences

CytoReason is a biotechnology company that develops AI-powered disease models to improve drug discovery and development processes.

Foresight Mental HealthHealthcare Digital

Foresight Mental Health provides therapy and psychiatry services both online and in-person, focusing on immediate availability and a range of mental health services including child and adolescent therapy, maternal mental health, and intensive treatment services.

Frontier BiolabsBiotech Life Sciences

Frontier Bio develops advanced vascular grafts and tissue platforms for creating engineered tissues. The company focuses on building the foundation for organ-scale tissue engineering.

GenecisClimate Clean Energy

Genecis Bioindustries is a climate biotech company turning organic waste into sustainable, biodegradable materials, offering a circular economy solution for products’ beginning and end of life.

Hypoint
InPharMDHealthcare Digital

InpharmD™ is a digital service that provides on-demand drug information to clinical pharmacists, enabling evidence-based care through AI-powered literature searches.

Kernal BioBiotech Life Sciences

Kernal Bio is a biotech company developing onco-selective mRNA therapeutics aimed at improving cancer patients' survival and quality of life. The company is engineering cells inside the body using AI-designed, selective mRNA and targeted LNP.

New CultureFood Beverage

New Culture is revolutionizing how cheese is made with animal-free dairy products that stretch, melt, and taste like the real deal. They combine traditional cheese-making and innovative food science to create cheese that is kinder on animals, the planet, and human health.

Orbit FabAerospace Defense

Orbit Fab is building the in-space propellant supply chain, providing spacecraft refueling services to enable a sustainable and thriving in-space economy.

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Research briefRead more
Asymmetry Ventures Research Overview & Investment Philosophy Asymmetry Ventures (stylized as Asymmetry VC) is a seed-stage venture capital firm founded in 2018 and based in San Francisco. The firm has earned recognition as a top-tier early-stage investor, being selected by Business Insider as one of the "Seed 100" rankings of the world's top early-stage investors. Asymmetry Ventures' mission is ex

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