Sierra Ventures

Reify Health provides cloud-based software that accelerates the development of new and life-saving therapies. Through its business entities, StudyTeam and Care Access, the company delivers best-in-class trial optimization technology and provides a pioneering decentralized clinical trial infrastructure that makes clinical research accessible for anyone, anywhere.

Phenom People is an HR tech company that leverages AI to enhance the talent experience, helping enterprises hire faster, develop better, and retain employees longer.

Spectro Cloud provides an enterprise Kubernetes management platform called Palette, designed to simplify the deployment and management of Kubernetes clusters across various environments, including cloud, on-premises, and edge locations.

Pioneers in AI for quantum technology, providing solutions for quantum computing, navigation, and sensing.

Astronomer provides a fully-managed data operations platform powered by Apache Airflow, enabling organizations to streamline their data workflows and enhance data observability.

Pantomath is a company focused on automating data operations using innovative AI-driven solutions, helping teams deliver reliable data with less noise.

Endor Labs is an AI-native application security platform that enhances software development by identifying, prioritizing, and fixing vulnerabilities in code, dependencies, and containers using deep program analysis and AI.

Cimulate delivers AI-native shopping experiences, powered by context, through its platform CommerceGPT, which enhances product discovery and search capabilities for e-commerce.

Augmentus provides no-code adaptive robotic automation solutions for high-mix and complex manufacturing, enabling users to program robots easily for various applications such as welding, surface finishing, and material removal.

Sedai offers a self-driving cloud platform that optimizes compute, storage, and data using patented reinforcement learning to reduce costs, improve performance, and prevent outages.

Amplify Partners backs deeply technical enterprise founders in infrastructure, data, AI/ML, developer tools, and security. They take very small initial checks and provide repeated follow-on support, operating like a technical think tank that publishes deep, operator-style essays on AI, data, and developer tooling that founders treat as reference material.

Founded by former Google CEO Eric Schmidt, Innovation Endeavors invests exclusively at the intersection of three converging technical forces they call the Super Evolution — ubiquitous sensors, advanced machine learning and cloud systems, and robotics/3D printing/CRISPR. The firm runs an invite-only unconference called Curiosity Camp and operates a venture creation program that helps form founding teams before ideas exist rather than backing pre-packaged startups.

Operates a Sage model where CEOs and serial founders embed as hands-on operators, sometimes interim leaders, hatch and prototype startups internally, and bring hundreds of millions in follow-on capital. The firm also hatches new companies internally by having partners identify opportunities, do research and prototyping, then match concepts with founders—functioning partially like a startup studio while running a traditional venture fund.