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S3 Ventures

Austin, TX · Invests in US · Website

SeedSeries ASeries BB2B SaaSAI & Machine LearningDeveloper ToolsCybersecurityFintechHealthcare & BiotechEnterprise SoftwareHealthcare & Digital HealthDeveloper Tools & InfrastructureFintech & PaymentsSecurity & Cybersecurity

Thesis

Patient Capital. True Resources. Big Impacts. S3 backs visionary founders building in Business Software and Healthcare Technology. Unique single-LP structure (a multi-billion dollar philanthropic family office) enables patient, flexible investing unconstrained by traditional VC fundraising cycles. Founded in Texas in 2005 — the largest and longest-serving VC native to Texas.

Likely not a fit for

Consumer apps, pure consumer internet, or companies outside Business Software and Healthcare Technology

How they invest

Lead or follow
Usually leads
Typical decision
~2 months
Involvement
Takes a board seat
Fund status
Actively deploying
Assets under mgmt
$1B
Decision process
Investment Committee

Partners & team

11 contacts on file

EE

Eric Engineer

General PartnerGeneral Partner · Primary contact

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e•••@s3•••.com

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AM

Anthony Marfisi

AssociateAssociate

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a•••@s3•••.com

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BR

Brian R. Smith

PartnerManaging Director

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b•••@s3•••.com

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CP

Charlie Plauche

General PartnerGeneral Partner

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c•••@s3•••.com

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AP

Aaron Perman

General PartnerGeneral Partner

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a•••@s3•••.com

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JC

Joe Curry

PrincipalPrincipal

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j•••@s3•••.com

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NB

Nicole Bentz

PrincipalVice President

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n•••@s3•••.com

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KH

Kevin Haley

AssociateAssociate

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k•••@s3•••.com

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WO

Will Omberg

AssociateAssociate

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w•••@s3•••.com

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KD

Kathryn Deebel

Platform & OpsDirector of Platform & Network

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k•••@s3•••.com

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SG

Shelley Graves

Platform & OpsController

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s•••@s3•••.com

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Portfolio

Alleviant MedicalHealthcare Digital

Alleviant Medical is focused on developing interatrial shunt therapy for patients with heart failure, currently evaluating its effectiveness through FDA-approved clinical trials.

AllstacksEnterprise Software

Allstacks is a Software Engineering Intelligence Platform that provides on-demand exhaustive AI-analysis, complete visibility into engineering investments, and tools for project forecasting and developer experience.

ArpioEcommerce Marketplaces

Arpio.com is a domain for sale. The company is not currently active.

AtmosphereTVMedia Entertainment

Atmosphere TV is the largest streaming TV platform built for businesses, providing engaging entertainment and digital signage solutions tailored for commercial environments.

BuildForceEnterprise Software

BuildForce is a workforce management platform that specializes in connecting electrical contractors with qualified electricians. It offers tools for hiring, managing, and tracking electricians efficiently, ensuring projects stay on schedule and within budget.

CereTaxEnterprise Software

CereTax is a cloud-native, AI-powered platform that automates sales tax calculation, validation, and compliance for businesses managing complex transactions across multiple jurisdictions. It provides transparent logic, audit-ready reporting, and seamless integrations with existing systems.

ControlRoomsEnterprise Software

ControlRooms is an AI troubleshooting assistant designed for chemical processing plants, helping to detect issues early and alert the right teams to mitigate risks and improve operational efficiency.

CroglSecurity Cyber

Crogl is an AI-driven security platform that automates the investigation of security alerts, enabling security analysts to focus on critical threats while ensuring every action is documented and auditable.

DataBahn
Flex VascularHealthcare Digital

Flex Vascular is a pioneering medical device company specializing in vessel preparation and access management for arteriovenous (AV) fistulas and grafts, as well as peripheral vascular disease. The company's flagship technology, the FLEX Vessel Prep™ System, utilizes proprietary Kinetic Endovascular Micro-incision Creation (KEMIC) technology to optimize vessel preparation.

Folia HealthHealthcare Digital

Folia Health provides a platform for individuals to track their health and share insights to improve personalized healthcare. It focuses on home-reported outcomes to help patients and researchers understand chronic conditions better.

HydrolixEnterprise Software

Hydrolix provides a real-time data platform designed for high-volume log data management and analytics, enabling observability across distributed infrastructures.

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Research briefRead more
S3 Ventures Research Investment Thesis S3 Ventures is the largest and longest-serving venture capital firm native to Texas, investing nationwide since 2005. Founded by Brian R. Smith — a former IBM engineer who took his startup Crossroads Systems public on NASDAQ at age 29 — S3 has built a distinct identity around "Patient Capital. True Resources. Big Impacts." What fundamentally differentiates S3

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