OS Fund
Los Angeles, CA · Invests in US · Website
Check size
🔒 $•• – $••Thesis
Biology is programmable. We invest in visionary entrepreneurs whose platform-level science innovations rewrite operating systems across biology, materials, diagnostics, and AI. By backing founders developing programmable biology, synthetic biology, advanced materials, computational therapeutics, and biotech infrastructure, we enable the creation of breakthrough technologies that solve global challenges.
Likely not a fit for
No consumer applications without scientific depth. No non-technical founding teams. No incremental improvements. Only paradigm-shifting science backed by exceptional founders with deep domain expertise.
How they invest
- Lead or follow
- Leads or follows
- Typical decision
- ~2 weeks
- Warm intro
- Not required
- Involvement
- Takes a board seat
- Fund status
- Actively deploying
- Assets under mgmt
- $250M
- Decision process
- Partnership vote
Partners & team
4 contacts on file
Portfolio
Ginkgo Bioworks is a biotechnology company that designs custom microbes for a variety of applications, including pharmaceuticals, agriculture, and industrial processes.
Atomwise uses machine learning to discover novel, drug-like molecules for drug development, focusing on immune and inflammatory diseases.
Synthego is a biotechnology company that specializes in CRISPR gene editing and molecular diagnostics, providing innovative solutions for genetic engineering and diagnostics.
Arzeda is a protein design company that creates new designer proteins and enzymes to address challenges in food production, nutrition, and sustainable materials. They utilize Intelligent Protein Design Technology, combining physics-based design and AI to innovate across various industries.
Pivot Bio develops crop nutrition technologies that harness the power of nature to deliver nitrogen to plants, enabling microbes to convert atmospheric nitrogen and provide it to crops throughout the growing season. Their solutions aim to improve profitability, predictability, safety, and sustainability for farmers.
Just Egg is a plant-based alternative to traditional eggs, offered by Justforall.com. It features vegan recipes, including scrambles and frittatas.
Verge Genomics is pioneering an AI-powered drug discovery platform that utilizes human genomics and machine learning to develop new drugs for complex diseases, focusing on conditions like ALS, Parkinson's Disease, and Frontotemporal Dementia.
OpsReady is a work completion software for industrial operations, focusing on outcomes and streamlining processes through an all-in-one mobile application.
Elysium Health translates scientific advancements in aging research into accessible health products and technologies, focusing on supplements that promote healthy aging.
Lygos is an industrial biotechnology company developing biobased sustainable solutions to improve everyday products. Our technology platform enables better economics and unlocks the power of organic acids specialty chemicals, enabling our partners to offer sustainable alternatives to legacy petroleum-based plastics, fragrances, home and personal care products, and more.
Recent activity
- Mar 2022
Arzeda
Series B · Investor
- Dec 2020
Kenota Health
Series A · Investor
- Sep 2019
A-Alpha Bio
Seed · Lead
- Sep 2018
uBiome
Series C · Investor
- Jul 2018
Lygos
Series B · Lead
OS Fund in the news
Livemint
Bryan Johnson Net Worth: A look at anti-ageing influencer's key ventures and assets
Jul 2025
Briefly News
Bryan Johnson's net worth: how he built a $400M fortune through tech
May 2025
American Council on Science and Health
Longevity or Marketing? Dissecting the Claims of the Blueprint Protocol
Feb 2025
Morocco World News
Meet Bryan Johnson, AKA ‘Zero’, The Man On a Mission to Stay Young Forever
Feb 2024
Fortune
Bryan Johnson, the tech CEO spending millions to be 18 again, follows 4 rules in life
Jul 2023
Fortune
How did Bryan Johnson make his millions?
Feb 2023
renaissancecapital.com
OSAAU IPO News - Healthcare technology-focused SPAC OS Acquisition withdraws $150 million IPO
Nov 2022
The University of Chicago Booth School of Business
Bryan R. Johnson, ’07 (XP-76)
Mar 2022
AgFunderNews
Ginkgo Bioworks to go public at $15bn valuation as agrifood SPAC frenzy continues
May 2021
Fierce Biotech
Bankrupt microbiome startup uBiome to liquidate assets, shutter operations
Oct 2019
GeekWire
A-Alpha Bio raises $2.8M for genetically engineered drug discovery platform
Sep 2019
University of Chicago News
How one entrepreneur is tackling humanity’s most pressing problems
Sep 2019
The University of Chicago Booth School of Business
Braintree's Bryan Johnson is Looking Ahead to Frontiers Unknown
May 2019
KNKX
Venture capitalist says 'deep technology' is the solution to climate change
Dec 2018
Polsky Center for Entrepreneurship and Innovation
The Modern-day Explorer: Chicago Booth Alum Turns to Deep-tech Innovations to Save the World
Sep 2018
Business Insider
Why Braintree Founder Bryan Johnson Invests in Tech's Most Neglected Markets
Aug 2018
Fierce Biotech
Verge Genomics gathers $32M to trial its AI-built neuroscience drugs
Jul 2018
Medium
OS Fund — Building A Global Biological Immune System | by Bryan Johnson | Future Literacy
May 2018
Global Venturing
Numat structures $12.4m investment
Apr 2018
MIT Sloan
TwoXAR announces Series A in quest to collapse drug discovery timelines
Mar 2018
businessinsider.com
A startup that uses software to discover new drugs just raised $10 million
Mar 2018
AgFunderNews
UPDATE: Arzeda Closes Series A on $15.2m for Plant-Based Computational Protein Production, Led by OS Fund
Nov 2017
GeekWire
Seattle startup raises $12M to 'rewrite the software of life' (with a little help from the technology behind beer)
Jul 2017
SynBioBeta
Synthego Raises $41 Million in Series B Financing Led by 8VC to Advance CRISPR Genome Engineering
Jan 2017
SynBioBeta
Synthetic Biology Startup Lygos Closes $13 Million Venture Financing to Target Trillion Dollar* Oil-Based Specialty Chemical Industry
Dec 2016
Bryan Johnson – Medium
Kernel’s Quest to Enhance Human Intelligence
Oct 2016
IEEE Spectrum
New Startup Aims to Commercialize a Brain Prosthetic to Improve Memory
Aug 2016
The Business Journals
Biotech startup 3Scan raises $14 M to expand the abilities of its robotic microscope
Jul 2016
AgFunderNews
Ginkgo Bioworks Eyes Agriculture After Raising $100m for GE Microbe Manufacturing Business
Jun 2016
The Guardian
'We have this remarkable ability to create any kind of world we can imagine'
Oct 2015
Fortune
Crazy, insane start-ups are this tech investor’s meat and potatoes
Oct 2014
tech.co
$100M Fund to Rewrite Operating System of Everyday Life
Oct 2014
Similar firms
Bioscience investor translating grant-funded research into venture-scale companies, with a pipeline centered on engineering biology using robotic cloud labs and computational design for human health and planetary sustainability. The firm grew directly out of a philanthropic grants program at the Thiel Foundation that funded highly speculative science before spinning into a traditional venture fund.
Writes first institutional checks ($500k–$5M) at earliest stages for compute-applied chemistry and biology ventures (therapeutics, industrial biotech, climate, materials), led by an advanced-degree scientific team.
Early-stage accelerator for synthetic biology and life sciences that gives scientist-founders lab independence with co-located BSL-rated wet labs and extended runway via SOSV integration reserving 75% for follow-ons. The world's first startup accelerator focused specifically on synthetic biology and life sciences, created to give scientists independence as founders rather than forcing them into traditional academic or big-pharma tracks. The program runs its own large wet-lab infrastructure where portfolio companies co-locate and build in BSL-rated labs owned by the fund, while providing an unusually long runway of capital through deep integration with SOSV's fund structure that reserves 75% for follow-on rounds.
Exclusive synthetic biology investor focused on companies replacing industrial inputs with biology-based alternatives, led by a UCSF-trained PhD cell biologist offering deep research expertise and global Latin America–Europe reach.
Invests in early-stage life sciences companies, often backing founders when they are no more than an idea.
Research briefRead more
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