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First Star Ventures

Boston, Massachusetts · Invests in US · Website

Pre-SeedSeedAI & Machine LearningDeveloper ToolsHealthcare & BiotechClimate & EnergyRoboticsHardware & DevicesBiotech & Life SciencesRobotics & AutomationClimate & Clean EnergyDeveloper Tools & InfrastructureHealthcare & Digital Health

Thesis

Invest with conviction in visionary, technical founders inventing the future with frontier computing technology. Focus on computing×real-world startups (techbio, climate, robotics, industrial infrastructure). Enforce strict rebuildability bar—won't invest if 3-5 Google engineers could recreate product in 3-12 months. Position against SaaS/consumer playbook; future venture outliers will be very different.

Likely not a fit for

No non-technical founders, no commoditized SaaS, no consumer-only apps, no investments that fail rebuildability bar

How they invest

Lead or follow
Usually follows
Typical decision
~2 weeks
Warm intro
Preferred
Involvement
Advisor
Fund status
Actively deploying
Decision process
Partnership vote

Partners & team

3 contacts on file

DV

Drew Volpe

General PartnerFounding Partner · Primary contact

+ Pitch

LinkedIn profile

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ML

Millie Liu

General PartnerFounding Partner

+ Pitch

m•••@fi•••.vc

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TB

Teddy Blank

PartnerPartner

+ Pitch

t•••@fi•••.vc

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Portfolio

JellyfishEnterprise Software

Software Engineering Intelligence Platform that helps organizations effectively manage engineering teams, improve operational efficiency, and align engineering work with business outcomes.

ZanskarClimate Clean Energy

Zanskar is an AI-native geothermal energy company focused on unlocking geothermal resources using data and advanced technologies to deliver affordable, carbon-free energy.

EnzymitBiotech Life Sciences

Enzymit is pioneering a new era of biomanufacturing through the creation of novel enzymes that address unmet market needs, focusing on cell-free production methods that are faster, simpler, cost-effective, and sustainable.

Nomic.bioBiotech Life Sciences

Nomic.bio offers affordable and flexible proteomics solutions, including the Omni 1000 platform that quantifies 1000 informative proteins with high fidelity. Their nELISA technology revolutionizes multiplexed immunoassays, enabling high-throughput protein profiling.

Salient PredictionsEnterprise Software

Salient Predictions provides AI-powered weather forecasts and analytics, leveraging machine learning and deep neural networks to deliver accurate predictions from daily to yearly timeframes, with applications in various industries including agriculture, energy, and finance.

Scoot ScienceEnterprise Software

Scoot Science provides the SeaState platform, which transforms environmental, fish inventory, and operations data into site-specific ocean forecasts and fish health insights for fish farms.

EnpoweredClimate Clean Energy

EnPowered helps you transform your electricity use into new revenue and bottom-line savings. Our expert guidance and AI-assisted technology make participation in energy market programs easy without disrupting your core revenue-generating operations.

GradientSecurity Cyber

Gradient Technologies offers a passwordless multi-factor authentication (MFA) solution that eliminates traditional authentication methods, providing a frictionless user experience while enhancing security against credential-based cyberattacks.

TursoDeveloper Tools Infra

Turso is the lightweight database that scales to millions of instances, designed for the agentic future. It serves as a complete SQLite drop-in replacement, built to support AI agents and intelligent applications by deploying databases everywhere, including servers, browsers, and devices.

Vista PathHealthcare Digital

VistaPath is modernizing pathology labs using computer vision and artificial intelligence. They provide clients with significant quality, workflow, and strategic benefits with the overall goal of delivering improved results for pathologists, clinicians, and patients. The Sentinel is the company’s first product.

Native VoiceMedia Entertainment

Native Voice Studios develops AI companions based on fully licensed characters, distributing them on various devices to foster engagement and entertainment. They focus on creating compliant, high-quality AI interactions.

The KanarySecurity Cyber

Kanary is a web app designed for personal data removal, offering self-guided and fully-managed services to help users remove their personal information from data brokers and the internet.

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Research briefRead more
First Star Ventures Research Investment Thesis First Star Ventures believes in investing with conviction in visionary, technical founders inventing the future with frontier computing technology. Founded in 2014 and based in Cambridge/Boston, Massachusetts, First Star partners with entrepreneurs solving real-world problems using cutting-edge technology. They distinguish themselves through a strict

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